Increasing interest in eSource keeps the issue of data integration between research systems (EDC, CTMS, CDMS, etc.) and healthcare systems (EHR etc.) as a consistent want for sponsors, clinical investigators and regulators. The new PHUSE Working Group project Investigating the Use of FHIR in Clinical Research looks at how the HL7 FHIR standard could be used as a fundamental part of the clinical trial process in the future.